I downloaded the ProfitUI reborn and tried it out. It works great while in the game but i have a problem once i log out. I have to load the UI again each time i log in and reopen all but the first hotbar since all but the primary bar are closed for some reason.
Ive obviously done something wrong at installation.
Did you delete/rename your [server].[toon]_eq2_uisettings.ini file before first loading the UI? And even if you did, do it again, since it is apparently not saving correctly.