When I play games, I use the
Nostromo Speedpad n50.
I mapped the movement keys in a WASD configuration.
Then assigned a key for closest enemy, tab enemy, attack, waypoint
For the joystick pad by the thumb, I mapped it to
Inventory, Map, Spellbook, info sheet (Stat page)
I find it really help when moving around in the game.
I have yet to get really advanced with the button combos yet though.
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DarkCable