I'm guessing your running win7 or winVista...
Searching our forums "Error Opening Database File" brings up threads with the solution to right click and run as administrator.
Those operating systems disallow 3rd party apps to write to the program files folder. So if you have EQ2 installed in the program files folder you will need to give the application admin access. Or you can move EQ2 into something like c:\games\EverQuest II\ and not have to give it admin access.
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