[g4nd4lf]

Had this problem too. It's a little bit weird that this only happens when you change icon sizes via the profit prefs when the game is running.

If you have a preferred default size simply edit the file

_ProfitUI_Settings_EffectsIconSizes.txt

This is my file with detrimental icons largened a little bit:

<?xml version="1.0" encoding="utf-8"?>
<Page Name="EffectsIconSizes">
	<Text Name="BeneficialEffectsIconSize">30</Text>
	<Text Name="DetrimentalEffectsIconSize">36</Text>
	<Text Name="TargetEffectsIconSize">15</Text>
	<Text Name="ImpliedTargetEffectsIconSize">15</Text>
</Page>

Overlapping should not happen if icon size is specified that way.

Hope it works for you too.