Hmm. Are you playing windowed by chance? I do not know of anything that moves the entire UI at once, so the only thing that comes to mind is that it's windowed and you moved the window.
If not, you might be able to fix things in a relatively simple fashion if you use the same configuration on multiple characters. In that case, just do a /load_uisettings and load them from a character with a normal appearance.
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