Either you selected the wrong EQ2 path (some people have several installations without them realizing it) or you were already in game when you edited the file and did not restart the client or you ran the ProfitUI updater afterwards and did not have _ProfitUI_QuickRaidButtons.txt on ignore, thus overwriting your changes again. Everything else should provide an error message (unless you are on Vista, things may be different there I assume).
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