What Calain said, but as you are on Unrest that is probably not your issue.
I can however not immediately think of any other reason, either. Is there any message in chat? There should be either something about "<....> could not be found" or something like that or "that spell or ability is no longer available". Maybe even something about you not having that item in your inventory. The more information I have the better.
Also I assume you have not removed, modified or replaced any windows from the ProfitUI set.
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