I've always been a minimalist when it comes to UI's.
Resolution is 1280x1024. The bottom actually consists of 3 windows, although you can't tell from the screenshot.
Leftmost is groupchat, says, raidchat. The middle window is located directly below the player/target windows. It consists of all battle info. The rightmost window displays ooc, auctions, shouts, loot messages.
I use 3 hotbars. The leftmost vertical hotbar I keep stocked with individual and group buffs. The horizontal hotbars are mostly offensive spells, with some utility that are macro'd to different keys on my keyboard.
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