Check out the various complete sets available. My Fetish sets are designed to minimize screen clutter and include a slew of extra features.
Regarding your specific comments...
1) Chat window tabs can be seperated into multiple windows, just drag the tab out of the main chat window area. Fetish also allows you to hide the chat input area for each chat window.
2) Hotkey bars can individually be resized for a vertical layout if you prefer. The only drawback to a vertical layout is that the bank changer will be on the side. Fetish automatically hides the changer on mouseout. Other hotkey specific mods with changer on top or bottom are available on this site.
3) Maintained and effect bars are also resizable for horizontal or vertical layout.
4) Activatable slots can be dragged from the inventory window to a hotbar for quick activation. Once in a hotbar, you can configure the hotbar to whatever layout you prefer. The Fetish inventory window is customized to shrink and colapse down to just the most frequently used slots and includes quick activation buttons.
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