QuickCast and QuickCure problems...
 

Been having two issues lately:

1) On my Warlock and my wife's mage (haven't tested it on a healer yet), the QuickCure buttons don't seem to work 75% of the time. I have to manually target the person and cast it from my hotbar.

2) the QuickCast buttons (the ones numbered 1-5 over the health bars in group/raid), while working for my Warlock, do not work on my wife's wizard. She mouse-overs it, sees the spell name, but when she clicks it, it doesn't work and gives a "spell or ability no longer available" error.

Has anyone else had any issues with this and maybe found a solution?

This sounds like the camping/battlegrounds issue. With this issue once you /camp to another toon or zone to battlegrounds the game does not always properly update the dynamic data for the buttons. As for a fix, I do not know of one.

Silat

If you go linkdead or do BG and forget to relog you can do this to fix them
and dont have to relog anymore.

Create a macro and add a command. Enter the following text:
/show_window Custom.ProfitUI_SubClassDetector

GM9 Suggested a fix for this in another thread. I have implemented the changes locally and if the test shows it working as intended I will be posting it later today.

Silat