Screenshots are at 1600x1200 resolution. Most stuff should position the same if you set all windows to default locations (there's a button for that in Game Options). Hotkeys were individually positioned.
Regarding cast bar, its tagged as user movable. If you're not seeing the move cursor, the window probably is locked. I found the easiest way to repossition the cast bar is to start casting your gate home spell (keeps the cast bar up a long time) then unlock and move as needed. Just move your toon to cancel the gate when ur done
Oh, and the letterbox setting could be throwing some stuff off. Things near the letterbox frame seam to want to move with it.